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目的探讨超重、肥胖对儿童血压、血脂、胰岛素抵抗与C-反应蛋白(CRP)的相关关系。方法在哈尔滨市随机抽取6所小学,对432名7~11岁健康儿童进行体格、血压测量及血脂、血糖、胰岛素和C反应蛋白(CRP)检测。结果超重肥胖儿童的检出率为35.64%,在对年龄性别修正后,超重肥胖儿童与正常儿童相比血压、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)和胆固醇(TD)显著升高,偏相关分析显示CRP与体质指数(BMI)、腰高比(WHt R)和HOMA-IR相关,偏相关系数分别是0.183(P<0.05)、0.319(P<0.01)和0.171(P<0.01)。结论超重肥胖可引起儿童脂代谢紊乱和高血压,且在超重肥胖儿童体内BMI、WHt R、体脂率和胰岛素抵抗(IR)与CRP存在一定相关关系。
Objective To investigate the relationship between overweight and obesity in children with blood pressure, lipids, insulin resistance and C-reactive protein (CRP). Methods Six elementary schools were randomly selected in Harbin. Physical, blood pressure and blood lipid, blood glucose, insulin and C-reactive protein (CRP) were measured in 432 healthy children aged 7 to 11 years. Results The prevalence of obesity in overweight children was 35.64%. After adjusting for age and sex, overweight and obesity children had significantly higher blood pressure, insulin resistance index (HOMA-IR), triglyceride (TG) and cholesterol (TD) than those of normal children Partial correlation analysis showed that CRP was correlated with BMI, WHt and HOMA-IR. The partial correlation coefficients were 0.183 (P <0.05), 0.319 (P <0.01) and 0.171 (P < 0.01). Conclusions Overweight and obesity may cause disorder of lipid metabolism and hypertension in children. BMI, WHt R, body fat percentage and insulin resistance in overweight and obese children are correlated with CRP.