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1.盐酸普鲁卡因静脉滴注: 哮喘持续状态患儿60例(男34,女26),1～13岁,经用抗生素、激素、氨茶碱均无效,改用盐酸普鲁卡因治疗。方法为盐酸普鲁卡因3～5 mg/kg溶入5%或10%葡萄糖注射液50～100ml中静脉缓慢滴注,每天一次。疗效:一次用药后临床控制15例,显效25例,好转20例;二次用药后临床控制共44例;三次用药后全部病例达到临床控制。使用过程中未发现不良反应。作用机理初步认为是药物对支气管平滑肌有解痉作用,此外尚有镇静作用,能抑制心肌的兴奋性。 2.维生素K_1肌内注射: 支气管哮喘患儿38例(男23,女15),8个月～13岁。方法为维生素K_1肌内注射,2岁以内2～4mg/次,2岁以上5～10mg/次,2～3次/天。疗效为显效18例,好转17例,无效3例。未发现毒性反应。认
1. procaine hydrochloride intravenous infusion: 60 cases of persistent asthma in children (male 34, female 26), 1 to 13 years old, with antibiotics, hormones, aminophylline are invalid, the switch to procaine hydrochloride treatment. Method for the procaine hydrochloride 3 ~ 5 mg / kg into 5% or 10% glucose injection 50 ~ 100ml intravenous slow infusion, once daily. Efficacy: a control after clinical control in 15 cases, markedly effective in 25 cases, improved in 20 cases; the second control after a total of 44 cases of clinical control; three cases of all the cases to achieve clinical control. No adverse reactions were found during use. Mechanism of action Initially that the drug has bronchial smooth muscle spasm, in addition there is a sedative effect, can inhibit the excitability of myocardium. 2. Vitamin K_1 intramuscular injection: 38 cases of bronchial asthma (male 23, female 15), 8 months to 13 years old. Method for vitamin K_1 intramuscular injection, within 2 years of 2 ~ 4mg / time, 2 years of age 5 ~ 10mg / time, 2 ~ 3 times / day. Efficacy of 18 cases markedly improved in 17 cases, 3 cases were ineffective. No toxic reaction was found. recognize