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目的探讨多学科综合护理干预对消化性溃疡患者氧化应激和Th17/IL-17炎症轴的影响,为临床工作提供理论依据。方法选择2015年11月-2016年11月本院消化性溃疡患者92例作为研究对象,根据随机数字表法分为观察组和对照组,各46例,观察组患者采用多学科综合护理干预,对照组患者采用常规护理干预,探讨多学科综合护理干预在消化性溃疡患者中运用的效果及对患者氧化应激和Th17/IL-17水平的影响。结果治疗后MDA、AOPP均较治疗前下降,且观察组低于对照组患者;治疗后抗氧化物GSH-PX、SOD较前明显上升,且观察组高于对照组患者;治疗后观察组患者血清中IL-17、IL-21、TNF-α水平均低于对照组患者;治疗后观察组患者情绪角色、心理健康、疼痛、躯体角色、躯体功能、社会功能、活力、总健康评分均优于对照组,上述差异均有统计学意义(P<0.05)。结论多学科合作延续护理运用在消化性溃疡患者中有助于改善患者氧化应激和炎症状态,改善患者生存质量。
Objective To investigate the effect of multidisciplinary nursing intervention on the oxidative stress and the axis of Th17 / IL-17 inflammation in patients with peptic ulcer and provide a theoretical basis for clinical work. Methods A total of 92 patients with peptic ulcer in our hospital from November 2015 to November 2016 were randomly divided into observation group (46 cases) and control group (46 cases). The observation group received multidisciplinary comprehensive nursing intervention, The control group of patients using routine nursing intervention to explore the effect of multidisciplinary comprehensive nursing intervention in patients with peptic ulcer and the impact of oxidative stress and Th17 / IL-17 levels. Results After treatment, MDA and AOPP decreased compared with before treatment, and the observation group was lower than the control group. After treatment, the GSH-PX and SOD in the observation group were significantly higher than those in the control group after treatment; The levels of IL-17, IL-21 and TNF-α in serum were lower than those in the control group. The emotional status, mental health, pain, body function, physical function, social function, vitality and total health score in the observation group after treatment were all excellent In the control group, the above differences were statistically significant (P <0.05). Conclusions Multidisciplinary cooperation in continuation of nursing application in patients with peptic ulcer helps to improve the patient’s oxidative stress and inflammatory status and improve the quality of life of patients.