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用抗早孕实验和大鼠子宫离体实验，研究了醋酸棉酚与米索前列醇抗早孕的协同作用。结果表明，早孕小鼠单服米索，其终止早孕作用微弱；当与棉酚合用时，对小鼠的抗早孕作用增强。对离体大鼠子宫，米索有明显的增强宫缩作用，而棉酚则无影响，但早孕大鼠ｐｏ棉酚８０ｍｇ·ｋｇ－１·ｄ－１，３ｄ后其子宫对米索的敏感性较对照组有显著提高。大鼠于妊娠ｄ６～８ｐｏ棉酚或米索，或两药剂量的一半合并用药，可使子宫蜕膜组织损伤，而以两药合用组最为严重，但子宫孕酮受体含量和分布与对照组相似。结果提示，两药合用有协同抗早孕作用。
With anti-early pregnancy and rat uterine in vitro experiments to study the synergistic effect of gossypol acetate and misoprostol anti-early pregnancy. The results showed that early pregnancy mice single dose of misoprostol, its termination of early pregnancy weak; when combined with gossypol, the role of anti-pregnancy in mice increased. On isolated rat uterus, misoprostol significantly enhanced contractility, while gossypol had no effect, but the early pregnancy rats po gossypol 80mg · kg-1 · d-1,3d after the uterus sensitive to misoprostol Sex than the control group increased significantly. Rats in pregnancy d6 ~ 8po gossypol or misoprostol, or half the dose of two drugs combined can make uterine decidua tissue injury, and the most serious combination of the two drugs, but the uterine progesterone receptor content and distribution and control Group similar. The results suggest that the two drugs synergistic effect of anti-pregnancy.