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目的:总结子宫畸形患者行IVF-ET治疗的妊娠结局。方法:回顾性分析行IVF-ET治疗的35例先天子宫畸形患者(子宫畸形组)的临床结局,随机抽取同期子宫正常、单纯输卵管因素不孕症患者110例作为对照组。结果:患者年龄、不孕年限、BMI、bFSH、bLH、促排卵天数、FSH使用总剂量、hCG注射日E2、受精率、卵裂率、临床妊娠率、着床率、多胎率和流产率组间均无统计学差异,但子宫畸形组的分娩孕周、活婴体质量、早产率均差于对照组,差异有统计学意义(P<0.05),所有新生儿均未观察到畸形。结论:要重视子宫畸形患者的早期诊断和临床处理,建议患者在获得多胎妊娠后减为单胎,同时加强孕期及分娩过程中的检查与监护,以期获得更好的妊娠结局。
Objective: To summarize the pregnancy outcome of IVF-ET in patients with uterine malformations. Methods: The clinical outcomes of 35 cases of congenital uterine malformation (uterine malformation group) treated by IVF-ET were retrospectively analyzed. One hundred and ten patients with normal uterine infertility and simple tubal factor infertility were randomly selected as the control group. RESULTS: The patient’s age, duration of infertility, BMI, bFSH, bLH, days of ovulation, total FSH dose, E2 on hCG injection day, fertilization rate, cleavage rate, clinical pregnancy rate, implantation rate, multiple pregnancy rate and abortion rate There was no significant difference between the two groups. However, gestational age, live birth weight and premature birth rate in uterine malformation group were all worse than those in control group (P <0.05). No deformities were observed in all newborns. Conclusions: We should pay attention to the early diagnosis and clinical treatment of patients with uterine malformations. It is suggested that patients should be reduced to singleton after multiple pregnancy and strengthen the examination and supervision during pregnancy and childbirth so as to obtain better pregnancy outcomes.