论文部分内容阅读
目的观察国产注射用奥沙利铂(L-OHP)为主的联合化疗治疗晚期大肠癌的临床疗效和毒副反应。方法治疗组为A组,对照组为B组。A组L-OHP130mgm2,静脉滴注,第1天,注射用亚叶酸钙(CF)200mgm2,静脉滴注,第1～5天,氟脲嘧啶脱氧核苷(FUDR)400mgm2,静脉滴注,第1～5天,21天为一个周期;B组CF200mgm2,静脉滴注,第1～5天,FUDR400mgm2,静脉滴注,第1～5天,21天为一个周期。2周期后评定疗效。结果共收入病人51例,A组26例,有效率为46.2%,不良反应主要为感觉神经毒性、恶心、呕吐和白细胞下降;B组25例,有效率12.0%,不良反应主要为恶心、呕吐和白细胞下降,无神经毒性。结论L-OHP,联合CF+FUDR化疗较CF+FUDR化疗疗效提高,病人的耐受良好,是治疗晚期大肠癌安全有效的方案。
Objective To observe the clinical efficacy and side effects of domestic injection of oxaliplatin (L-OHP) -based combination chemotherapy in the treatment of advanced colorectal cancer. Methods The treatment group was A group and the control group was B group. A group of L-OHP130mgm2, intravenous drip, the first day, the injection of calcium folinate (CF) 200mgm2, intravenous drip, the first 5 days, fluorouracil deoxynucleoside (FUDR) 400mgm2, 1 to 5 days, 21 days for a cycle; B group CF200mgm2, intravenous drip, the first 5 days, FUDR400mgm2, intravenous drip, 1 to 5 days, 21 days for a cycle. After 2 cycles assessment of efficacy. Results A total of 51 patients were enrolled in the study. A group of 26 patients with an effective rate of 46.2%, adverse reactions mainly sensory neurotoxicity, nausea, vomiting and leukopenia; B group of 25 cases, the effective rate was 12.0%. The main adverse reactions were nausea and vomiting And leukopenia, no neurotoxicity. Conclusions L-OHP combined with CF + FUDR chemotherapy is more effective than CF + FUDR chemotherapy and is well tolerated. It is a safe and effective treatment for advanced colorectal cancer.