强心甙狄高辛是治疗心衰及心律失常的重要药物。因毒性高、治疗性血浆药物浓度范围狭窄,故监测血浆狄高辛浓度非常重要。最近Graves及Pudek等自肾损害成人及早产儿血浆中检出一种内源性物质,能使狄高辛免疫测定呈假阳性结果。其中某些患者这种秋高辛样免疫活性物质大量增加,足以影响狄高辛测定值的作用。作者及Pudck等曾证实,胆汁中存在大量狄高辛样免疫活性物质。因此促使作者检测肝脏病患者血浆狄高辛样免疫活性物质浓 Cardiac glycosides Digoxin is an important drug for the treatment of heart failure and arrhythmia. Due to the high toxicity and the narrow therapeutic plasma drug concentration range, it is important to monitor plasma digoxin concentrations. Recently, Graves and Pudek and other renal damage in adults and premature children detected an endogenous plasma substance, make digoxin immunoassay showed false positive results. In some of these patients, a significant increase in this kind of alpine-like immunoreactive substance is sufficient to affect the effect of the digoxin test. The authors and Pudck et al. Have demonstrated that there is a large amount of digoxin-like immunoreactive substance in bile. Thus prompting the author to detect plasma digoxin-like immunoreactive substance in patients with liver disease