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目的:探讨生长激素(GH)对不同年龄卵巢储备功能趋于低下患者在IVF-ET中是否有影响。方法:行IVF-ET的卵巢储备功能趋于低下的不孕患者240例,均采用普通长方案降调节。观察不同年龄患者加用GH后的卵巢反应,并以不加用GH者为对照组。结果:年龄<35岁GH组81例,对照组90例;年龄≥35岁GH组39例,对照组30例。年龄<35岁的不孕症患者Gn使用天数、Gn使用支数、hCG注射日E2水平、获卵数、2PN受精率、优质胚胎率、种植率、妊娠率等观察指标,对照组和GH组间均无统计学差异(P>0.05)。年龄≥35岁的不孕症患者Gn用量(Gn支数)实验组显著低于对照组,有统计学差异(P<0.05);hCG注射日E2水平、获卵数实验组显著高于对照组,差异有统计学意义(P<0.05)。结论:GH对年龄<35岁卵巢储备功能低下患者的卵巢反应及IVF-ET治疗结局无影响;而对年龄≥35岁则有一定影响,可减少Gn使用量,提高hCG注射日的E2水平,增加获卵数。
OBJECTIVE: To investigate whether growth hormone (GH) has an effect on IVF-ET in patients whose ovarian reserve tends to be lower at different ages. Methods: 240 cases of infertility patients with lower ovarian reserve function of IVF-ET were treated with normal long-term regimen. Observe ovarian response after adding GH in different age groups, and take GH without GH as control group. Results: Age <35 years, GH group 81 cases, control group 90 cases; age 35 years old GH group 39 cases, control group 30 cases. Gn use number, Gn use count, E2 level on hCG injection day, number of oocytes retrieved, 2PN fertilization rate, quality embryo rate, implantation rate, pregnancy rate and other indicators in patients with infertility aged <35 years old, There was no significant difference between the two groups (P> 0.05). Gn levels (Gn counts) in patients with infertility≥35 years old were significantly lower than those in the control group (P <0.05); E2 level on the day of hCG injection and the number of oocytes in the experimental group were significantly higher than those in the control group , The difference was statistically significant (P <0.05). CONCLUSION: GH has no effect on the ovarian response in patients with ovarian reserve less than 35 years of age and the outcome of IVF-ET treatment, but has an impact on the age of 35 years or older, which can reduce the use of Gn and increase the level of E2 on hCG injection day, Increase the number of oocytes.