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目的：：本文通过检测终末期肾病（ESRD)患者中MMPs/TIMPs的含量,探讨其在终末期肾病中心血管中的意义,评价透析充分性对ESRD患者心血管事件的影响。方法：（1）选取2013年6月至2014年6月泸州医学院附属医院肾脏内科收治住院的ESRD患者（为期观察一年），进行不同分组行MMPs/TIMPs及相关指标的检测；（2）并通过超声心动图进一步证明血液透析对心血管事件的影响。结果：（1）MMPs/TIMPs均较正常对照组有所升高，其中MMP-10随着透析时间的延长而逐渐下降,TIMP逐渐升高(P<0.05)；（2）超声心动图显示：与正常对照组相比，ESRD患者左心室扩张明显，左室收缩末期内径减小，心脏射血分数明显减低，透析越充分，心血管疾病发生率越小，差异有统计学意义（P<0.05）。结论：（1）MMP-10在终末期肾脏病中可能是预测心血管事件的标志物；（2）透析充分性是评价ESRD患者心血管事件发生的一个重要影响因素。“,”Objective This article by detecting ESRD (ESRD) in MMPs / TIMPs content of the patient, discuss MMPs / TIMPs significance in ESRD cardiovascular, and to evaluate the impact of dialysis adequacy of cardiovascular events in patients with ESRD.Method (1) Select from June 2013 to June 2014, Affiliated Hospital of Luzhou Medical Nephrology ESRD patients admitted to hospital (for a period of observation of one year), different grouping row MMPs TIMPs detection / and related indicators; (2) by echocardiography further proof of hemodialysis on cardiovascular events.Results (1) MMPs / TIMPs was increased compared with the control group, in which MMP-10 with shorter dialysis time gradually increased, TIMP decreased (P<0.05) ;(2) echocardiography showed that compared with the control group, left ventricular dilatation in patients with ESRD significantly, reduced left ventricular systolic diameter, ejection fraction was significantly reduced, the most obvious change in the non-dialysis patients, the difference was statistically significant (P <0.05) .Conclusions (1) MMP-10 in end-stage renal disease might be a marker to predict cardiovascular events; (2) dialysis adequacy evaluation is an important factor for cardiovascular events in patients with ESRD.