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临床资料年龄分布为10～14岁,男女之比是1∶3,病程为2～5年不等,均以身材矮小为主诉;其临床症状均有不同程度的生长发育落后、乏力、畏寒、活动少、皮肤粗糙,腹胀、便秘等甲低症状。除1例外,均呈现甲低的特殊面容,但智力不低下,病程中都无一过性甲亢。仅有1例甲状腺肿大。无甲状腺手术及服抗甲状腺药物史。化验检查:4例患儿T_3、T_4均低于正常,T8H都增高,而TGA(抗甲状腺球蛋白抗体)和TMA(抗甲状腺微粒体抗体)增高,腕部骨龄明显落后。
Clinical data age distribution of 10 to 14 years old, male to female ratio is 1: 3, duration of 2 to 5 years, are mainly short stature; the clinical symptoms have varying degrees of growth and development lag, fatigue, chills , Less activity, rough skin, bloating, constipation, etc. A low symptoms. In addition to one exception, all presented a low special face, but intelligence is not low, no transient hyperthyroidism in the course of the disease. Only 1 case had goiter. No thyroid surgery and anti-thyroid drug history. Laboratory tests: 4 cases of T_3 and T_4 were lower than normal, T8H were increased, while TGA (anti-thyroglobulin antibody) and TMA (anti-thyroid microsomal antibody) increased, the wrist bone age was significantly behind.