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目的 研究低剂量舒必利对功能性消化不良 (FD)的治疗效果。方法 对我院门诊 2 0 0 1年 1月至 2 0 0 2年 12月间的 78例FD病人 ,随机分为治疗组 38例 ,用舒必利 10 0mg ,每日 3次 ,餐前服 ;对照组 4 0例 ,用西沙比利 5mg ,每日 3次 ,餐前服 ;疗程 4周。结果 治疗组显效率高于对照组 (P <0 0 5 ) ,且病人症状完全缓解停药后 3个月的复发率低于对照组 (P <0 0 5 )。结论 舒必利兼有抗抑郁作用和止呕、促进胃蠕动功能 ,治疗FD效果良好 ,且不良反应轻。
Objective To study the therapeutic effect of low-dose sulpiride on functional dyspepsia (FD). Methods 78 cases of FD patients from January 2001 to December 2002 in our hospital were randomly divided into treatment group (38 cases), sulpiride (100 mg), three times a day Group 40 cases, with cisapride 5mg, 3 times daily, pre-meal service; course of treatment for 4 weeks. Results The effective rate of the treatment group was significantly higher than that of the control group (P <0.05), and the symptom of complete remission was lower at 3 months after stopping the treatment than that of the control group (P <0.05). Conclusion Sulpiride both antidepressant and antiemetic, promote gastric motility function, FD treatment of good results, and mild adverse reactions.