青霉素类药物因其抗菌谱广而被广泛用于临床,但用药不当除直接影响药物的疗效外,也导致青霉素的耐药性,不良反应日趋增多,现就存在的问题探讨如下:1　青霉素溶媒的选择青霉素为β-内酰胺类,分子中存在着不稳定的β-内酰胺环。在干燥状态下稳定,在水溶液中除发生降解反应外,还发 Penicillins are widely used in clinical because of their wide antibacterial spectrum. However, the improper use of drugs not only directly affects the curative effect of drugs, but also leads to the resistance of penicillin and the increasing adverse reactions. The existing problems are discussed as follows: 1 Penicillin The choice of penicillins for the β-lactams, molecules exist in the unstable β-lactam ring. In the dry state of stability, in addition to the degradation reaction occurred in aqueous solution, but also made