论文部分内容阅读
检测了14例慢性血吸虫病(下称慢血)和25例晚期血吸虫病(下称晚血)患者外周血自发性抑制性T细胞(STs)功能,对所有慢血患者和15例晚血患者同时检测外周血T细胞亚群。结果慢血和晚血患者STs功能均显著增高,CD~+_3(全T细胞)百分比和CD~+_4(辅助性T细胞)/CD~+_8(抑制性/细胞毒T细胞)比值明显降低,CD~+_8细胞百分比升高,CD~+_8细胞百分比和CD~+_4/CD~+_8比值分别与STs功能呈正相关和负相关。对STs功能和T细胞亚群在慢性血吸虫感染免疫调控中的作用进行了讨论。
We examined the function of spontaneous inhibitory T cells (STs) in peripheral blood of 14 patients with chronic schistosomiasis (hereinafter referred to as “slow blood”) and 25 patients with advanced schistosomiasis (hereinafter referred to as late blood). All of the patients with slow blood and 15 patients with late blood At the same time detection of peripheral blood T cell subsets. Results The function of STs in patients with chronic and late blood was significantly increased, the percentage of CD ~ + _3 (total T cells) and CD ~ + _4 (T helper) / CD ~ + _8 (inhibitory / cytotoxic T cells) The percentage of CD ~ + _8 cells and the ratio of CD ~ + _4 / CD ~ + _8 were positively correlated and negatively correlated with the function of STs. The role of STs function and T-cell subsets in immune regulation of chronic schistosomiasis infection is discussed.