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嗜酸、嗜碱性粒细胞在变态反应中有着明显的选择性聚集现象.文章通过对IL-4诱导的内皮细胞表面粘附分子表达的检测及相应单抗阻断试验,证实IL-4对粒细胞粘附作用的选择性诱导主要是通过刺激内皮细胞VCAM-1表达增加实现的.
Eosinophils and basophils have obvious selective aggregation phenomenon in allergic reaction.According to the detection of IL-4-induced endothelial cell adhesion molecule expression and the corresponding monoclonal antibody blocking test, IL-4 Selective induction of granulocyte adhesion is mainly achieved by stimulating the increased expression of VCAM-1 in endothelial cells.