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目的 :探讨伤寒杆菌对肝脏的损害和对肝功能的影响。方法 :对 35 0例伤寒患者肝功能及乙型肝炎病毒(HBV)标记物的检测结果进行分析。结果 :2 30例 (6 5 .7% )出现ALT和AST升高 ,其中 83例 (36 .1% )伴有血清总胆红素 (STB)升高 ;32 0例进行HBV标记物检测 ,发现HBV感染 4 5例 ,伤寒重叠HBV感染率为14 .1% ,重叠感染组的ALT ,AST及STB均值比单纯感染组显著升高 (P <0 .0 5 )。结论 :伤寒患者中肝损害较常见 ,其中重叠HBV感染者肝损害程度更重 ,但重叠HBV感染者中肝损害的发生率并无明显升高。
Objective: To investigate the effects of Salmonella typhi on liver damage and liver function. Methods: The detection results of liver function and hepatitis B virus (HBV) markers in 35 0 typhoid patients were analyzed. Results: Elevated ALT and AST were found in 230 (65.7%) patients, of which 83 (36.1%) were associated with elevated serum total bilirubin (STB); 32 were HBV markers, 45 cases of HBV infection were found. The infection rate of HBV in typhoid fever was 14.1%. The ALT, AST and STB in overlap infection group were significantly higher than those in simple infection group (P <0.05). Conclusions: Liver damage is more common in patients with typhoid fever, in which patients with overlapping HBV infection have more severe liver damage, but there is no significant increase in the incidence of liver damage in patients with overlapping HBV infection.