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目的探索、研究勃起功能障碍(ED)和下尿路症状(LUTS)在药物治疗方面是否存在相关性。方法本组研究对象80例病人均患有ED和LUTS,分为3组,每例研究对象在初诊时,必须填写IIEF-5、IPSS评分表,作为研究开始的基线。A组服用两地那非,B组服用多沙唑嗪控释片,C组联合应用西地那非和多沙唑嗪控释片。用药6个月后再次填写IIEF-5和IPSS评分表以作对比。用方差分析检验方法,进行用药前后数据统计学分析。结果3组治疗前后IIEF-5、IPSS评分变化差异均有编者计学意义,C组(联合用药组)变化最大(P<0.001)。结论ED与LUTS相互影响,ED患者LUTS发生率明显升高,而LUTS患者的ED危险性亦显著增加。西地那非可显著改善ED患者合并的LUTS症状,多沙唑嗪可改善LUTS患者的性功能;西地那非联合多沙唑嗪治疗ED、LUTS患者具协同作用。
Objective To explore whether there is a correlation between drug treatment of erectile dysfunction (ED) and lower urinary tract symptoms (LUTS). Methods The subjects of this study were 80 patients with ED and LUTS, divided into three groups, each case of subjects at the time of the first visit, you must fill in the IIEF-5, IPSS score as the baseline for the study. Group A took both of those non-B, taking doxazosin controlled-release tablets, C combined with sildenafil and doxazosin controlled-release tablets. Six months after treatment, fill in again IIEF-5 and IPSS score table for comparison. Analysis of variance test method, before and after data statistical analysis. Results The changes of IIEF-5 and IPSS scores before and after treatment in both groups were statistically significant. The changes in group C (combination group) were the most significant (P <0.001). Conclusions ED and LUTS interact with each other. The incidence of LUTS in patients with ED is significantly higher than that in patients with LUTS. The ED risk in patients with LUTS is also significantly increased. Sildenafil can significantly improve the ED patients with LUTS symptoms, doxazosin can improve the sexual function of patients with LUTS; sildenafil combined with doxazosin ED, LUTS patients with synergistic effects.