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Objective: To describe the autofluorescence (AF) characteristics of choroidal neovascularization (CNV) in patients with age-related macular degeneration. Methods: Autofluorescence images of 65 consecutive eyes with CNV at various stages of evolution were analyzed. Twenty images were of recent-onset CNV (group 1), 8 were of eyes 1 to 6 months after CNV diagnosis (group 2), and 37 were late-sta ge CNV (group 3). Autofluorescence images from groups 1 and 2 were compared with fundus fluorescein angiographic images. Results: Group 1 showed areas of hyperf luorescence on fundus fluorescein angiography corresponding to areas of normal A F in 16 of 20 cases, with adjacent areas of increased AF in 13 cases. The main a reas of abnormal AF were larger than the main areas of abnormal fluorescence on fundus fluorescein angiography in 18 of the 20 cases. Groups 2 and 3 showed area s of decreased AF corresponding to areas of previous leakage on fundus fluoresce in angiography (in group 2) or atrophy. Conclusions: Preserved AF in group 1 ind icates viable retinal pigment epithelium initially, which has implications for v isual prognosis. Decreased AF in groups 2 and 3 indicates loss of retinal pigmen t epithelium and photoreceptors. Autofluorescence imagingmay increase our unders tanding of CNV in age-related macular degeneration.
Objective: To describe the autofluorescence (AF) characteristics of choroidal neovascularization (CNV) in patients with age-related macular degeneration. Methods: Autofluorescence images of 65 consecutive eyes with CNV at various stages of evolution were analyzed. Twenty images were of recent-onset CNV (group 1), 8 were of eyes 1 to 6 months after CNV diagnosis (group 2), and 37 were late-sta ge CNV (group 3). Autofluorescence images from groups 1 and 2 were compared with fundus fluorescein angiographic images. Results: Group 1 showed areas of hyperf luorescence on fundus fluorescein angiography corresponding to areas of normal AF in 16 of 20 cases, with adjacent areas of increased AF in 13 cases. The main a reas of abnormal AF were larger than the main areas of abnormal fluorescence on fundus fluorescein angiography in 18 of the 20 cases. Groups 2 and 3 showed area s of decreased AF corresponding to areas of previous leakage on fundus fluoresce in angiography (in group 2) or atrophy. Conclusions: Preserved AF in group 1 ind ic via via retinal pigment epithelium initially, which has implications for v isual prognosis. Decreased AF in groups 2 and 3 indicates loss of retinal pigmen t epithelium and photoreceptors. Autofluorescence imaging may increase our unders tinging of CNV in age -related macular degeneration.