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目的:探讨甲亢患者β2-微球蛋白含量与血脂水平的相关性。方法:以甲状腺功能亢进症患者40例作为观察组,另选择同期在我院进行体检的健康人群40例为对照组,分别于治疗前和治疗后检测患者血清和尿β2-微球蛋白、血外周血载脂蛋白、血脂,并进行血清和尿β2-微球蛋白与血脂的相关性分析。结果:治疗前甲亢组血清和尿β2-微球蛋白均高于对照组(P<0.01);TC、TG、HDL-C、LDL-C和APOB均低于对照组(P<0.01);治疗后,血清和尿β2-微球蛋白与治疗前相比均有所下降(P<0.01),TC、TG、HDL-C、LDL-C和APOB与脂类前相比均有所升高(P<0.01);血清和尿β2-微球蛋白与TC、TG、HDL-C、LDL-C和APOB均呈负相关。结论:甲亢患者血清和尿β2-微球蛋白与血脂关系密切,可作为评价患者脂质代谢状态和病情变化的重要指标。
Objective: To investigate the relationship between β2-microglobulin content and serum lipids in patients with hyperthyroidism. Methods: Thirty patients with hyperthyroidism were selected as the observation group. Another 40 healthy subjects in our hospital during the same period were selected as the control group. Serum and urinary β2-microglobulin and blood levels were measured before and after treatment Peripheral blood apolipoproteins, lipids, and serum and urinary β2-microglobulin and lipids in the correlation analysis. Results: Serum and urinary β2-microglobulin in patients with hyperthyroidism before treatment were significantly higher than those in the control group (P <0.01); TC, TG, HDL-C, LDL-C and APOB were lower than those in the control group After treatment, serum and urinary β2-microglobulin decreased compared with that before treatment (P <0.01), TC, TG, HDL-C, LDL-C and APOB increased P <0.01). Serum and urinary β2-microglobulin were negatively correlated with TC, TG, HDL-C, LDL-C and APOB. Conclusion: Serum and urinary β2-microglobulin in patients with hyperthyroidism is closely related to blood lipids, which can be used as an important index to evaluate the changes of lipid metabolism status and disease in patients with hyperthyroidism.