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局灶性癫痫中约15％的患者抗痫治疗效果差,并伴有行为和记忆功能障碍。作者以前的研究曾发现,中度控制的部分性癫痫患者,苯并二氮(BZD)受体在痫灶中密度减少,而痫灶外则正常。本研究试图证实BZD受体的改变与局灶性癫痫的严重程度是否有关,而耐药病例是否有特征性改变。 19例患者均为部分性癫痫,其脑MRI未见异常。将每日均有发作且对工作和智能均有影响者判为严重发作,共10例;其余9例为轻症发作 发作频率为每周1～数次至1年仅数次,均能正常工作,且发作对日
About 15% of patients with focal epilepsy have poor response to antiepileptic therapy with behavioral and memory dysfunction. The authors previous study found that, in moderately controlled patients with partial epilepsy, benzodiazepine (BZD) receptors were reduced in the epileptogenic zone but normal outside of the epileptogenic zone. This study sought to demonstrate whether changes in BZD receptors are associated with the severity of focal epilepsy and whether there is a characteristic change in resistance cases. All the 19 patients were partial epilepsy, and their brain MRI showed no abnormalities. Will have a daily attack and have an impact on work and intelligence were sentenced to severe attack, a total of 10 cases; the remaining 9 cases of mild episodes of seizures frequency of 1 to several times a week to only a few years, can be normal Work, and the attack on Japan