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为了探讨原发耐药性对肺结核短程化疗结果的影响,作者复习了近10年在非洲、香港及新加坡进行的12组有对照的肺结核短程化疗的研究,共有8,212例病人纳入科研观察,其中1,041例有原发耐药性:耐 INH 447例;耐 SM 327例;耐 RFP 2例;联合耐药计有:SM+INH 256例,RFP+INH 1例、RFP+SM 1例,RFP+SM+INH 7例。作者根据资料分析,获得以下主要结果:(1)化疗失败问题由敏感菌致病者,化疗失败不多,如2,530例采用1～2个月强化期包括 RFP的方案,治疗失败13例(0.5%),另3,177例采用含RFP 6个月方案,仅2例(0.01%)失败。而耐 INH
In order to investigate the impact of primary drug resistance on tuberculosis short-course chemotherapy outcomes, the authors reviewed 12 groups of controlled tuberculosis short-term chemotherapy in Africa, Hong Kong and Singapore over the last 10 years. A total of 8,212 patients were included in the study, of which 1,041 Cases of primary resistance: INH 447 cases resistant to SM 327 cases of resistance RFP 2 cases; combined resistance were: SM + INH 256 cases, RFP INH 1 case RFP SM in 1 case RFP SM + INH 7 cases. According to the data analysis, the authors obtained the following main results: (1) The problem of chemotherapy failure caused by the susceptible bacteria, the failure of chemotherapy, such as 2,530 cases of 1 to 2 months with RFP enhancement program, the failure of treatment in 13 cases (0.5 %), And the other 3,177 patients with RFP for 6 months, only 2 patients (0.01%) failed. And resistant INH