感染根管中细菌释放的毒性产物引起的刺激是根尖周炎的病因之一。为促使根尖周组织的愈合和修复,必须去除全部残髓组织、坏死性碎片、细菌和感染的牙本质。组织胺,一种增加血管渗透性的最有效的介体,存在于龋坏牙髓及炎症和坏死牙髓中,推测它与急性根尖周炎的发病有关。 One of the causes of apical periodontitis is irritation caused by bacterial products released from root canal infections. To promote the healing and repair of periapical tissue, it is necessary to remove all the residual pulp tissue, necrotic fragments, bacteria and infected dentin. Histamine, the most effective mediator of increased vascular permeability, is found in carious pulp and in inflammatory and necrotic pulp, suggesting that it is involved in the pathogenesis of acute apical periodontitis.