30年前就记载大约有95%以上的慢性粒细胞白血病患者ph’染色体阳性。以后又明确了是9号染色体和22号染色体之间有互相移位。进入80年代对基因水平的分析有了长足进步,清楚了9q34上的ABL基因和位于22q11上的BCR基因结合,即形成BCR-ABL嵌合体基因。如果将该基因导入到IL-3依赖性骨髓细胞株时,即可诱导其自主性增生和在体内发生肿瘤。如果将该基因移植导入小鼠骨髓细胞,就可以观察到和慢 Thirty years ago it was documented that more than 95% of patients with chronic myeloid leukemia ph ’chromosome positive. Later it was clear that there is a mutual shift between chromosome 9 and chromosome 22. In the 1980s, there has been a great progress in the analysis of gene levels. It is clear that the ABL gene on 9q34 and the BCR gene on 22q11 bind to form the BCR-ABL chimera gene. If this gene is introduced into IL-3-dependent myeloid cell line, it can induce its own proliferation and tumor in vivo. If the gene was transplanted into mouse bone marrow cells can be observed and slow