对１４４例患者随机对照研究恩丹西酮最佳量效关系。顺铂组：恩丹西酮ａ组８ｍｇ／化疗日、ｂ组１６ｍｇ／化疗日、ｃ组２４ｍｇ／化疗日，结果１～６天，３组差异显著（Ｐ＜０．０５），ｃ组止吐效最佳。非顺铂组：Ａ组，恩丹西酮８ｍｇ／日，Ｂ组灭吐灵２０ｍｇ／日，结果Ａ、Ｂ组１～４天差异显著（Ｐ＜０．０５），Ａ组较Ｂ组效佳。恩丹西酮８ｍｇ／日，无任何副作用，１６ｍｇ／日便秘发生率９％，２４ｍｇ／日，便秘发生率２２％，差异显著（Ｐ＜０．０５） Randomized controlled study of the best dose-effect relationship of ondansetron in 144 patients. Cisplatin group: ondansetron group 8mg/chemotherapy day, group b 16mg/chemotherapy day, c group 24mg/chemotherapy day, results 1 to 6 days, 3 groups were significantly different (P<0.05), group c only Efficacy best. Non-cisplatin group: group A, ondansetron 8 mg/day, group B metoclopramide 20 mg/day, the results were significantly different between groups A and B on days 1 to 4 (P<0.05), and group A was more effective than group B good. Ondansetron 8mg/day, without any side effects, incidence of constipation 16mg/day 9%, 24mg/day, incidence of constipation 22%, the difference was significant (P<0.05)