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为了观察动脉灌注顺铂DDP、5-FU、BLM治疗晚期牙龈癌的疗效,102例晚期牙龈癌患者均用DDP、5-FU、BLM方案治疗剂量:DDP60～80mg/(m2.d1),5-FU500～1000mg/(m2·d1),BLM8～16mg/(m2.d1)。给药方法随机分为动脉灌注治疗组(A组)51例,静脉滴入治疗组(B组)51例。结果近期缓解率A组76.47%、B组49.01%,两组比较,χ2=8.22,P=0.0047;中位生存期A组20个月、B组15个月;生存>1年患者A组占76.47%、B组占56.86%,两组比较χ2=4.412,P=0.036;>2年生存A组占49.02%,B组占29.41%,两组比较χ2=4.113,P=0.046。初步研究结果提示,动脉灌注治疗晚期牙龈癌的临床疗效优于静脉滴入疗法。
In order to observe the curative effect of arterial infusion of cisplatin DDP, 5-FU and BLM for advanced gingival cancer, 102 patients with advanced gingival cancer were treated with DDP and 5-FU and BLM respectively. DDP 60-80 mg / (m2.d1), 5 -FU 500-1000 mg / (m2 · d1), BLM8-16 mg / (m2.d1). Methods of administration were randomly divided into arterial infusion treatment group (A group) 51 cases, intravenous drip treatment group (B group) 51 cases. Results The recent remission rate was 76.47% in group A and 49.01% in group B, χ2 = 8.22, P = 0.0047; the median survival time was 20 months in group A and 15 months in group B; 76.47% in group B, 56.86% in group B, χ2 = 4.412, P = 0.036 in two groups, 49.02% in group A and 2 in group B, and 29.41% in group B, respectively. Preliminary findings suggest that arterial infusion of advanced gingival cancer clinical efficacy is superior to intravenous drip therapy.