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目的:通过对唾液隐血与牙龈出血的相关性分析,探讨以唾液隐血测试(salivary occult blood test,SOBT)判断牙龈炎症状态的可行性。方法:对45例受试者的刺激和非刺激性唾液进行隐血测试,结合牙龈探诊出血(bleeding on probing,BOP)阳性位点百分比,以BOP%≥15%者作为慢性龈炎组,其余为牙龈健康对照组作关联分析,并对比患者牙周基础治疗前后的BOP%及SOBT变化,探讨SOBT与牙龈炎症的相关性,评估以SOBT检测牙龈炎症的灵敏度与特异度,应用SAS6.12软件包对数据进行统计学分析。结果:慢性龈炎组与牙龈健康对照组的刺激性SOBT有显著差异(P<0.01),非刺激SOBT有显著差异(P<0.05)。30例接受牙周基础治疗的慢性牙龈炎患者,BOP%显著下降(P<0.01),63%刺激性与90%非刺激性SOBT阳性者牙龈炎症得到改善,均有显著差异(P<0.01)。非刺激SOBT的灵敏度为32.35%,特异度为100%;刺激性SOBT的灵敏度为88.24%,特异度为81.82%。结论:SOBT与牙龈炎症存在一定关联性,可作为判断个体牙龈炎症及牙周疗效的客观依据,对在大规模人群中早期牙龈炎症的判定和筛检具有一定价值。
OBJECTIVE: To investigate the feasibility of using salivary occult blood test (SOBT) to determine the status of gingival inflammation by analyzing the relationship between saliva occult blood and bleeding gums. Methods: The occult blood samples of 45 patients with stimulated and non-irritating saliva were collected. The percentage of positive sites of bleeding on probing (BOP) was calculated. The patients with BOP% ≥15% were selected as the chronic gingivitis group. The association analysis of Gingival healthy control group and comparison of BOP% and SOBT changes before and after periodontal basic treatment of patients, to explore the correlation between SOBT and gingival inflammation, to assess the sensitivity and specificity of detection of gingival inflammation by SOBT, using SAS6.12 software Data package for statistical analysis. Results: The SOBT of chronic gingivitis group was significantly different from that of healthy gingival control group (P <0.01), and non-stimulated SOBT was significantly different (P <0.05). BOP% was significantly decreased in 30 patients with chronic gingivitis who underwent periodontal treatment (P <0.01), while gingival inflammation was improved in 63% of patients with SPB and 90% of patients with non-irritant SOBT (P <0.01) . The sensitivity of non-stimulated SOBT was 32.35% and the specificity was 100%. The sensitivity of irritating SOBT was 88.24% and the specificity was 81.82%. CONCLUSIONS: SOBT is associated with gingival inflammation and may be used as an objective basis for judging gingival inflammation and periodontal efficacy in individuals. It is of value in the determination and screening of early gingival inflammation in a large population.