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为了观察2型糖尿病患者空腹及口服759葡萄糖后血清游离脂肪酸（FFA）的变化，探讨体内胰岛素调节FFA的能力是否减弱以及FFA与胰岛素抵抗的关系。采用比色法测定60例2型糖尿病患者（女31例，男29例，平均年龄55．30±12．27岁）空腹及OGTT2小时血清FFA水平，并同步测定血糖（PG）、胰岛素（INS）。同法测30例正常人作对照。胰岛素敏感性指数（ISI）＝1／（空腹血糖FPG×空腹胰岛素FINS）。结果：2型糖尿病患者空腹及2小时血清FFA、PG、INS均显著增高，ISI显著降低，与对照组比较P值分别为＜0．05或＜0．01；多元逐步回归分析显示，2小时FFA与胰岛素敏感性指数（ISI）呈明显负相关（P＝0．0304）。以上结果提示：2型糖尿病患者不仅存在着空腹FFA异常，而且存在着INS抑制FFA代谢的异常，餐后FFA的异常升高也与INS抵抗有关。
In order to observe the changes of serum free fatty acid (FFA) in fasting and oral 759 glucose in type 2 diabetic patients and to explore whether the ability of insulin in regulating FFA is weakened and the relationship between FFA and insulin resistance. The levels of serum FFA in 60 patients with type 2 diabetes mellitus (31 female, 29 male, mean age 55.30 ± 12.27 years) and 2 hours OGTT were measured by colorimetric method. The levels of plasma glucose (PG), insulin ). With the law to test 30 normal controls. Insulin sensitivity index (ISI) = 1 / (fasting blood glucose FPG × fasting insulin FINS). Results: Serum FFA, PG and INS were significantly increased and ISI was significantly lower in patients with type 2 diabetes at 2 h, P <0.05 or <0.01 respectively. The multiple stepwise regression analysis showed that 2 hours There was a negative correlation between FFA and insulin sensitivity index (ISI) (P = 0.0304). These results suggest that patients with type 2 diabetes not only have abnormalities of fasting FFA, but also have the abnormalities of INS inhibiting FFA metabolism. The abnormal increase of postprandial FFA is also associated with INS resistance.