As one of the most successful antitumor agents,paclitaxel occupies an important place among compounds exhibiting antitumor activity.Recently many studies ha
Spingosine-l-phosphate receptor 1(S1PR1) has attracted significant attention as a target for the treatment of autoimmune diseases and transplant rejection1.
Malignant tumor is a common and multiple disease severely threatening humans lives.Searching for new antitumor drugs with high effects and selectivity becom
Epidermal growth factor receptor (EGFR),one of the ErbB family of receptor tyrosine kinases,which plays indispensable roles in cell proliferation,survival,a
The marine natural product Psammaplin A(PSA),a brominated tyrosine derivative,was reported to inhibit in vitro HDACs(IC50=4.2nM) and DNMTs (IC50=18.6nM).Kee