大肠杆菌内毒素休克狗注射内毒素后血浆去甲肾上腺素迅速升高,在代偿期逐渐下降,接近于原水平,有的动物临死前又升至较高水平。正常麻醉狗静注654—2能使血浆中去甲肾上腺素短暂降低。内毒素休克大鼠虹膜的去甲肾上腺素荧光强度明显比对照鼠弱,注654—2鼠其荧光强度略高于休克大鼠,低于对照鼠。结果提示:654—2有间接抑制儿茶酚胺释放的可能性。 E. coli endotoxin shock after injection of endotoxin plasma norepinephrine rapidly increased in the compensatory phase decreased gradually, close to the original level, and some animals rose to a high level before dying. Normal anesthetized dogs intravenous injection of 654-2 norepinephrine in the plasma can be briefly reduced. Endotoxic shock rats iris noradrenaline fluorescence intensity was significantly weaker than the control group, note 654-2 rat fluorescence intensity slightly higher than the shock rats, lower than the control mice. The results suggest that: 654-2 has the possibility of indirectly inhibiting the release of catecholamines.