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庚型肝炎病毒(HGV)是一种新发现的黄病毒,核酸为RNA,其基因组结构与丙型肝炎病毒(HCV)和其他黄病毒相似。HGV能引起人类急性和持续性感染。从急性和暴发型肝炎病人血清经PCR扩增获得的HGVRNA的序列已测出。但是,HGV在这些疾病中的病因学地位尚未确定。该病毒虽经胃肠道外传播,可是,关于生物学特性以及传播途径所知甚少。本文就使用未经病毒灭活处理的血浆制品患者中发生HGV和HCV持续性感染的流行病学情况做了调查研究。
Hepatitis G virus (HGV) is a newly discovered flavivirus whose nucleic acid is RNA and whose genome is similar in structure to the hepatitis C virus (HCV) and other flaviviruses. HGV can cause acute and persistent human infections. The sequence of HGV RNA obtained by PCR amplification from the serum of acute and fulminant hepatitis patients has been determined. However, the etiological status of HGV in these diseases has not been established. Although the virus is transmitted parenterally, little is known about the biological properties and the route of transmission. This article investigates the epidemiology of persistent HGV and HCV infections in patients with plasma products that have not been virus-inactivated.