The thermal property of the polymerization of brain tubulin was studied by a highsensitivity differential scanning calorimeter. The phenomenon that heat flows increased and decreased consistently and obviously was observed. This phenomenon was called heat flow oscillation. It was probably correlated to the dynamic instability of microtubules. The effect of cisplatin on it was reported, too. The thermal of the polymerization of brain tubulin was studied by a high sensitivity conjugate scanning calorimeter. The phenomenon that heat flows increased and decreased consistently and obviously was observed. This phenomenon was called heat flow oscillation. It was probably correlated with the dynamic instability of microtubules The effect of cisplatin on it was reported, too.