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本文报告了重症肌无力症行胸腺切除术后危象23例,占我科手术治疗107例重症肌无力病例的21.5%,因危象死亡1例(4.3%)。通过对临床资料进行分析,作者认为,重症肌无力症行胸腺切除术后危象多数可以预测,发生危象与病人重症肌无力临床类型,术前服用抗胆碱酯酶药物剂量,是否合并胸腺瘤,术前曾发生危象以及肺通气功能障碍等因素有关。对于术前预测术后可能发生危象者,可于术毕行预防性气管切开,合理调整抗胆碱酯酶药物用药剂量,加强控制肺部感染等综合性防治措施。
This article reports 23 cases of post-thymectomy crisis of myasthenia gravis, accounting for 21.5% of the 107 cases of myasthenia gravis treated by our department. One case died of crisis (4.3%). Through the analysis of clinical data, the authors believe that the majority of crisis after thymectomy in patients with myasthenia gravis can predict the occurrence of crisis and the patient’s clinical manifestations of myasthenia gravis, preoperative anticholinesterase medication dosage, whether the merger thymus Tumor, preoperative crisis and pulmonary ventilation dysfunction and other factors. Preoperative prediction of postoperative crisis may occur in patients with tracheotomy prophylactic tracheotomy, rational adjustment of anticholinesterase drug dosage, and strengthen the prevention and treatment of pulmonary infection and other comprehensive prevention and treatment measures.