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目的 :观察地而硫与格列本脲相互作用对高血糖大鼠血糖水平的影响。方法 :采用葡萄糖氧化酶法测定血糖含量。结果 :肾上腺素 0 .2mg·kg- 1 显著升高大鼠血糖水平 ,格列本脲 0 .9mg·kg- 1 降低其诱发的大鼠高血糖水平。地而硫 1 0mg·kg- 1 ,ig ,1、2、3h后对格列本脲的降血糖作用无明显影响 (P >0 .0 5) ,而地而硫 1 0 0mg·kg- 1 则完全对抗了格列本脲的降血糖作用 ,且使血糖浓度进一步上升 ( P <0 .0 5) ,给药后 3h血糖水平升高至 31 1 .89± 7.95mg·dl- 1 ( P <0 .0 1 ) ,与对照组 ( 1 35.35±1 6.87mg·dl- 1 )相比上升了 1 30 %。结论 :地而硫 1 0 0mg·kg- 1 可拮抗格列本脲的降血糖作用
OBJECTIVE: To observe the effects of gemcitabine and glyburide on blood glucose in hyperglycemic rats. Methods: Glucose oxidase method was used to determine blood sugar content. Results: Adrenaline 0.2 mg · kg-1 significantly increased blood glucose levels in rats, and glibenclamide 0. 9 mg · kg-1 decreased the level of hyperglycemia in rats. And sulfur 10mg · kg-1, ig, 1,2,3 h after glyburide had no significant effect on hypoglycemic (P> 0.05), while the sulfur and sulfur 1000 mg · kg - 1 completely antagonized the hypoglycemic effect of glyburide and further increased the blood glucose level (P <0.05). After 3 hours of administration, the blood glucose level increased to 31 1 .89 ± 7.95 mg · dl -1 (P <0.01), which was 130% higher than that of the control group (1 35.35 ± 1 6.87 mg · dl-1). CONCLUSION: Di-sulfur sulfoxide (100 mg · kg -1) antagonized the hypoglycemic effect of glyburide