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本文论述了氧哌嗪青霉素和艮他霉素狗静脉单用或联用时的药代动力学。每天注射二次,为期36～37天,于第一周(为第1期)和最后一周(为第2期)输注药物时,按时采样,分别测出平均血药浓度;同时连续收集尿样二天,以测定药物的尿回收率。氧哌嗪青霉素和艮他霉素在狗血浆中的时间过程,可用二室开放型模型来描述。除了中室的分布容积(Vc)外,两种药物的其它动力学参数,第2期基本同于第1期,稳态分布容积(Vd_(ss))、总分布容积(Vd)无明显统计学变化。两种药物相比,氧哌嗪青霉素半衰期稍短、整体清除率稍长,分布容积、肾清除率在统计学上无差别。氧哌嗪青
This article discusses the pharmacokinetics of piperacillin and gentamicin dogs intravenous or in combination. Injected twice daily for a period of 36-37 days. When the drugs were infused in the first week (for the first period) and the last week (for the second period), the blood samples were taken on time and the average blood concentration was measured respectively. Meanwhile, urine The next two days to determine the drug’s urine recovery. The time course of piperacillin and gentamicin in dog plasma can be described by a two-compartment open model. Except for the chamber volume (Vc), the other kinetic parameters of the two drugs were similar to those of phase 1, steady state volume (Vd_ (ss)) and total volume of distribution (Vd) Learning changes. Two drugs, piperazine penicillin shorter half-life, the overall clearance rate slightly longer, the volume of distribution, renal clearance was statistically no difference. Oxypiperazine green