[Objective]To investigate the preventive protective effects and its mechanism of vitamin C and polysaccharide in Dioscrea pposite Thunb. on cadmium-induced liver damage in mice. [Methods]50 Kunming mice were randomly divided into control group,model group,D. pposite polysaccharides protection group,vitamin C protection group,D. pposite polysaccharides and vitamin C protection group. At the 7th day of feeding,the mice were given saline by gavage,and the mice in other groups were intraperitoneally injected with 3. 0 mg /kg CdCl2 solution. 24 hours after injection,blood was collected for ALT and AST test. Then,mice were sacrificed and the livers were removed for the calculation of hepatosomatic index(liver weight / body weight). Also,the liver homogenates were prepared for the determination of SOD and GSHPx activities and the of MDA and NO contents. [Results]Compared with the mice in model group,the liver-somatic index,serum ALT,AST activity,and contents of liver MDA and NO reduced,the activities of SOD and GSH-Px,and the content of GSH improved in D. pposite polysaccharides and vitamin C protection group(*P < 0. 05,**P < 0. 01). Compared with the model grfoup,the protective effects of D. pposite polysaccharides combined with vitamin C strengthened(**P < 0. 01). [Conclusions]The combination of D. pposite polysaccharides and vitamin C has preventive protection effects on cadmium-induced liver injury in mice by antagonizing cadmium and /or oxidative stress. The application of D. pposite polysaccharides combined with vitamin C had a synergistic effect. [Objective] To investigate the preventive protective effects and its mechanism of vitamin C and polysaccharide in Dioscrea pposite Thunb. On cadmium-induced liver damage in mice. [Methods] 50 Kunming mice were randomly divided into control group, model group, D. pposite polysaccharides protection group, vitamin C protection group, D. pposite polysaccharides and vitamin C protection group. At the 7th day of feeding, the mice were given saline by gavage, and the mice in other groups were intraperitoneally injected with 3.0 mg / kg The mice were sacrificed and the livers were removed for the calculation of hepatosomatic index (liver weight / body weight). Also, the liver homogenates were prepared for the determination of SOD and GSHPx activities and the of MDA and NO contents. [Results] Compared with the mice in model group, the liver-somatic index, serum ALT, AST activity, and contents of liver MDA and NO reduced, the ac tivities of SOD and GSH-Px, and the content of GSH improved in D. pposite polysaccharides and vitamin C protection group (* P <0.05, ** P <0.01). Compared with the model grfoup, the protective effects of D. pposite polysaccharides combined with vitamin C strengthened (** P <0.01). [Conclusions] The combination of D. pposite polysaccharides and vitamin C has preventive protection effects on cadmium-induced liver injury in mice by antagonizing cadmium and / or oxidative stress. The application of D. pposite polysaccharides combined with vitamin C had a synergistic effect.