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本文叙述了近年来免疫进孕疫苗研究的发展概况,对HCG疫苗发展趋势及存在问题作了简要介绍,GnRH疫苗可用于男性避孕,但需睾酮替代治疗,亦可用于产后妇女,以延长哺乳期妇女的不排卵期。oFSH疫苗目前已进入Ⅰ期临床试验,是第一个试用于人类的男性避孕疫苗,可使受试者发生少精或无精症,从而发生不育。另外,栋树油可激发局部细胞介导的免疫反应,诱发细胞因子,转而杀死精子或胚胎,造成不育。
This article describes the development of immunization of pregnant women in recent years, the development of HCG vaccine trends and existing problems were briefly introduced, GnRH vaccine can be used for male contraception, but the need for testosterone replacement therapy can also be used for postpartum women to prolong lactation Women do not ovulate. The oFSH vaccine has now entered Phase I clinical trials and is the first male contraceptive vaccine to be tested in humans, resulting in infertility with either oligospermia or azoospermia. In addition, building tree oil can stimulate the local cell-mediated immune response, induce cytokines, in turn kill sperm or embryos, resulting in infertility.