国内外对急性肝坏死治疗曾采用多种降氨及对抗假性神经递质等药物,以及血液或血浆交换法,交叉循环肝脏灌注,活性炭血液灌洗,聚丙烯腈膜血液透析等方法,虽常可逆转昏迷状态,但疗效欠佳,并未能降低病死率。我们最近应用与氨基酸代谢有密切相关的两种激素(胰高血糖素、胰岛素)、14氨基酸注射液及东莨菪碱联合疗法,成功地抢救了一例输血后急性肝坏死患者,结合文献复习报道如下。 Domestic and foreign treatment of acute liver necrosis has used a variety of anti-ammonia and anti-pseudo-neurotransmitters and other drugs, and blood or plasma exchange, cross-recirculation of liver perfusion, activated carbon blood lavage, polyacrylonitrile membrane hemodialysis and other methods, although Often reversal of coma, but poor efficacy, failed to reduce mortality. We recently successfully applied a combination of two hormones (glucagon, insulin), 14 amino acid injection and scopolamine, which are closely related to amino acid metabolism, to successfully rescue a patient with acute hepatic necrosis after transfusion, which is reported in the literature review.