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目的观察雷贝拉唑与多潘立酮联合应用治疗非甾体抗炎药所致上消化道疾病疗效。方法选择北京积水潭医院消化内科门诊上消化道疾病患者同时服用非甾体抗炎药(NSAIDs)80例,患者随机分为2组,A 组40例治疗前停服 NSAIDs,口服雷贝拉唑片10 mg 每日1次,多潘立酮10 mg 每日1次;B 组另40例,继续服用 NSAIDs,同时口服雷贝拉唑片10 mg QD,多潘立酮10 mg 每日3次,2组疗程均为4周。结果 A 组痊愈21例,显效12例,有效7例;痊愈率52.5%,愈合率82.5%;B 组痊愈19例,显效12例,有效9例;痊愈率47.5%愈合率77.5%,两组比较,痊愈率和愈合率 A 组稍高于 B 组,两组差异无显著性(P>0.05)。结论新型高效质子泵抑制剂雷贝拉唑和胃动力剂多潘立酮联合应用可以在不停用 NSAIDs 的情况下促进溃疡愈合,加快胃排空,减轻上消化道不适症状,达到患者满意的效果。
Objective To observe the efficacy of rabeprazole and domperidone in the treatment of upper gastrointestinal diseases caused by NSAIDs. Methods Eighty patients with upper gastrointestinal diseases in the gastroenterology outpatient department of Beijing Jishuitan Hospital were randomly divided into two groups. A group of 40 patients stopped taking NSAIDs before treatment and oral rabeprazole tablets 10 mg once daily, domperidone 10 mg once daily, and 40 patients in group B continued NSAIDs. Oral rabeprazole 10 mg QD and domperidone 10 mg three times a day were also administered week. Results In group A, 21 cases were cured, 12 cases were markedly effective and 7 cases were effective. The cure rate was 52.5% and the healing rate was 82.5%. In group B, 19 cases were cured, 12 cases were effective and 9 cases were effective. The cure rate was 47.5% and healing rate was 77.5% In comparison, the cure rate and healing rate in group A were slightly higher than those in group B, with no significant difference between the two groups (P> 0.05). Conclusion The new highly effective proton pump inhibitor rabeprazole combined with gastric motility agent domperidone can promote ulcer healing without NSAIDs, accelerate gastric emptying and relieve symptoms of upper digestive tract discomfort, and achieve satisfactory results in patients.