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乙酰唑胺(Acemzolamide)是一种碳酸酐酶抑制剂,通过抑制肾小管细胞碳酸酐酶阻止氢离子的合成,使肾小管不能重吸收碳酸氢盐,从而碱化尿液,用以代替大剂量甲氢喋呤(HDMTX)治疗时碱化尿液所需的碳酸氢钠。作者报道了10例骨肉瘤患者接受13疗程HDMYX(7例1疗程,3例2疗程),开始治疗前用生理盐水500ml水化30分钟,随后把8g/m~2HDMTX加入5％萄萄糖液内滴注,于6个多小时滴完,然后每6小时交替滴注生理盐水和5％葡萄糖1升,至少36小时。在开始滴注HDMTX时给予500mg的乙酰唑胺,然后每隔6小时给1次,直至48小时,检测血中氨甲喋呤(MTX)水平。除了发生呕吐外,乙酰唑胺给予口服。如果按上处理尿液pH<7.5,在30多分钟内静滴
Acemizolamide is a carbonic anhydrase inhibitor that inhibits the synthesis of hydrogen ions in renal tubular cells by preventing the tubular reabsorption of bicarbonate to alkalize urine to replace the bolus Sodium bicarbonate needed to alkalize urine during methotrexate (HDMTX) treatment. The authors reported 10 patients with osteosarcoma received 13 courses of HDMYX (7 cases of a course of treatment, 3 cases of 2 courses), before starting treatment with saline 500ml hydration for 30 minutes, then 8g / m ~ 2HDMTX added 5% glucose solution Instillation, drip over 6 hours, and then every 6 hours alternating infusion of normal saline and 5% glucose 1 liter for at least 36 hours. Administration of 500 mg of acetazolamide on instillation of HDMTX followed by 1 dose every 6 hours up to 48 hours was followed by methotrexate (MTX) levels in the blood. In addition to vomiting, acetazolamide is given orally. If press on the urine pH <7.5, intravenous infusion in more than 30 minutes