一般原理有些药物可通过中枢抑制来降低已升高的动脉血压。早在本世纪年60代末,经实验证明中枢降压部位之前,就认为中枢神经系统内存在降压部位的可能性。就利血平而言,其中枢性的降压机制在它的抗高血压作用中占有不重要的位置,而它的节后交感神经元末梢效应是重要的。关于利血平中枢降压作用的本质没有详细地了解。咪唑衍生物可乐宁是已知的具有明显中枢作用方式的第一个药物,现在已详细闸明。可乐宁中枢降压作用一经确定,而 General Principles Some medications can reduce elevated arterial blood pressure through central suppression. As early as the late 60s of this century, the center proved to be hypotensive sites in the central nervous system after being proved by experiments. In the case of reserpine, its central antihypertensive mechanism plays an insignificant role in its antihypertensive effect, and its postganglionic sympathetic neuronal endings are important. The nature of the hypotensive effect of reserpine is not well understood. Imidazole Derivatives Clonidine is the first known drug known to have a central mode of action and is now fully documented. Clonidine core hypotensive effect is determined, and