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目的探究山楂、泽泻、决明子与紫色红曲霉混合发酵产物(调脂中药红曲)对食源性高脂血症大鼠血脂水平的调节作用。方法以高脂饲料连续饲喂SD大鼠4周建立高脂血症动物模型,将实验大鼠分为对照组、模型组、调脂中药红曲预防组、脂必泰胶囊阳性组、大米红曲组、调脂中药红曲治疗组。分别连续给药4周,测定各组大鼠血清中总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的水平变化。结果调脂中药红曲预防组造模同时连续给药4周后,大鼠血清TC、TG、LDL-C水平显著降低(P<0.001),HDL-C水平显著升高(P<0.05)。造模4周后给药4周的治疗实验结果表明,与给药前组相比,大米红曲组大鼠血清TC、LDL-C水平显著降低(P<0.01),而TG、HDL-C水平变化不明显;调脂中药红曲组和脂必泰组大鼠血清TC、TG、LDL-C水平显著降低(P<0.05、0.01),HDL-C水平显著升高(P<0.05、0.01),且其对高脂血症大鼠血脂的调节作用优于大米红曲组。对比肝脏指数和脾脏指数发现调脂中药红曲具有较好的安全性。结论调脂中药与红曲霉混合固态发酵所得产物可有效抑制食源性高脂血症的形成,对食源性高脂血症大鼠血清血脂水平有良好的调节作用,发酵产物中中药调脂成分与红曲调脂成分具有协同作用。
Objective To investigate the regulatory effect of hawthorn, Alisma orientalis, cassia seed combined with Monascus purpureus on the blood lipid level of food-induced hyperlipidemic rats. Methods The SD rats were fed with high-fat diet for 4 weeks to establish hyperlipidemia animal model. The rats were divided into control group, model group, rosiglitazone-prophylaxis group, Zhibitai capsule positive group, Song group, lipid-lowering Chinese medicine konjac group. The rats in each group were continuously administered for 4 weeks. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) Variety. Results Serum levels of TC, TG and LDL-C were significantly decreased (P <0.001) and HDL-C levels were significantly increased (P <0.05) after four weeks of continuous administration. The results of the treatment for 4 weeks after 4 weeks of model making showed that the levels of serum TC and LDL-C were significantly decreased (P <0.01), while the levels of TG, HDL-C (P <0.05, 0.01), and HDL-C levels were significantly increased (P <0.05, 0.01) ), And its regulation of blood lipids in hyperlipidemic rats is superior to that of rice red yeast rice. Comparing the liver index and spleen index found that lipid-lowering Chinese medicine Monascus has better safety. Conclusion The product obtained by the mixed solid-state fermentation of Chinese herbal medicine and monascus can effectively inhibit the formation of food-borne hyperlipidemia and regulate the serum lipid level in food-induced hyperlipidemic rats. Ingredients and syphilis lipid composition synergies.