论文部分内容阅读
糖尿病尤其是病程5年以上的糖尿病是胰腺癌发生的一个重要危险因素,胰岛素抵抗及其介导的高胰岛素血症通过激活胰岛素/胰岛素样生长因子受体信号通路,促进细胞恶性增殖、侵袭及转移,诱使胰腺癌的发生发展。而胰腺癌合并糖尿病的患者,其糖尿病多数是在胰腺癌确诊前的3年内被发现或与胰腺癌同时诊断,很可能是胰腺癌的一个早期表现。因此针对新发糖尿病(病程在3年以内)或长期罹患糖尿病的患者应提高警惕,必要时进行相关辅助检查,有助于胰腺癌的及早诊断。
Diabetes mellitus is one of the most important risk factors for pancreatic cancer. Diabetes mellitus, especially over 5 years, is an important risk factor for pancreatic cancer. Insulin resistance and its hyperinsulinemia promote the proliferation and invasion of cells by activating the insulin / insulin-like growth factor receptor signaling pathway and Transfer, induce the occurrence and development of pancreatic cancer. In patients with pancreatic cancer and diabetes, most of their diabetes is diagnosed within 3 years prior to the diagnosis of pancreatic cancer or pancreatic cancer at the same time, it is likely to be an early manifestation of pancreatic cancer. Therefore, new-onset diabetes (duration of less than 3 years) or long-term patients with diabetes should be vigilant, if necessary, related auxiliary examination, contribute to the early diagnosis of pancreatic cancer.