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呼吸暂停、颅内出血和癫痫发作是常见的,并以各自的临床特点而共存。作者发现脑室管膜下出血(SEP-IVH)的早产儿比没有SEP-IVH者需要较大剂量茶碱才能控呼吸暂停,其中一些病人并存有癫痫发作接受鲁米那治疗。为了解茶碱需要量增加原因究属SEP-IVH本身或与鲁米那应用有关。作者对以下三组病人进行对比研究:第1组(10名),仅有呼吸暂停;第2组(10名),有呼吸暂停及SEP-IVH,1、2组均用茶碱治疗;第3组(9名)有呼吸暂停、SPE-IVH及癫痫发作,用茶碱及鲁米那治疗。呼吸暂停根据12小时呼吸运动描记波诊断,指呼吸暂停>20″,且伴有紫绀、苍白、心动过缓(心率<80bpm),并除外了其他可治疗的引起呼吸暂停的原
Apnea, intracranial hemorrhage and seizures are common and coexist with their own clinical features. The authors found that preterm infants with subependymal hemorrhage (SEP-IVH) required greater doses of theophylline to control apnea compared with those without SEP-IVH, some of whom had epileptic seizures with luminal therapy. The reason for the increased demand for theophylline belongs to SEP-IVH itself or to the use of luminal. The authors compared the following three groups of patients: group 1 (n = 10) with apnea only; group 2 (n = 10) with apnea and SEP-IVH, group 1 and group 2 with theophylline; Three groups (n = 9) had apnea, SPE-IVH, and seizures treated with theophylline and luminal. Apnea is diagnosed based on a 12-hour respirogram with apnea> 20 "and with cyanosis, pale, bradycardia (heart rate <80bpm) and exclusion of other treatable apnea-initiating