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进行性播散性组织胞浆菌病是一种由荚膜组织胞浆菌(histoplasma capsulatum)所致的少见的系统性感染,如不经治疗,常可致死.用二性霉素B适当治疗,一般能痊愈.但常易复发,剂量小时更为明显.二性霉素B需要长期胃肠道外给药,且常有一些副作用.因而,需要有一个毒性低、疗效高和给药方便的药物用于治疗进行性播散性组织胞浆菌病及其他一些系统性真菌病.酮康唑(Ketoconazole)是一种新的咪唑类的药物,在体外具有抗某些真菌的活性,包括荚膜组织胞浆菌.与双氯苯咪唑(miconazole)不同,由于酮康唑水中的溶解度、口服吸收好,产生有效的血清浓度(给药200mg～400mg后2～4小时达2～4μg/ml).初步的经验说明:本药可有效地用于治疗慢性皮肤粘膜念珠菌病、球孢子菌病和副球孢子菌病.因而可认为本药是“治疗真菌病的重大改革”.
Progressive disseminated histoplasmosis is a rare, systemic infection caused by histoplasma capsulatum, which can be fatal if left untreated. Adequate treatment with amphotericin B , But generally easy to relapse, the dose is more obvious hours.Friendomycin B need long-term parenteral administration, and often have some side effects.Therefore, there is a need for a low toxicity, high efficacy and convenient administration Medications for the treatment of progressive disseminated histoplasmosis and other systemic mycoses Ketoconazole is a new imidazole drug that has in vitro activity against certain fungi including pods Different from miconazole, due to the solubility and good oral absorption of ketoconazole in water, an effective serum concentration is obtained (2-4 μg / ml after 2 to 4 hours after administration of 200 mg to 400 mg) ) Preliminary experience shows that: The drug can be effectively used for the treatment of chronic cutaneous mucocutaneous candidiasis, coccidioidomycosis and paraspinalis disease, so that the drug is “a major reform of the treatment of fungal disease.”