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本文报道收集1984～1989年6年间由国产硫酸链霉素(SM)所致毒性反应共42例.其中男26例,女16例,7～9个月4例,10～12个月12例,1～2岁16例,2～3岁10例.原发病:支气管肺炎21例,急性扁桃体炎7例,颈淋巴结核2例,肺门淋巴结核4例,大叶性肺炎6例,脓胸2例.用药情况:42例均为SM治疗量(15～30mg/kg/日)分次肌注.其中36例并用了青霉素钠盐,6例结核病患者并用了雷米封口服.用SM后毒性反应出现最快1天,最迟14天.临床表现:烦躁、哭闹、睡眠不稳或易惊者5例,揪头发或(和)抠耳、抓口唇17例,头痛伴呕吐12例,睡眠中突然尖叫、哭闹4例,步态不稳、举动不准伴恶心者4例.预后:停药后毒性反应消失时间最快8小时,最慢12天.随访33例中有2例聋哑,14例高频听力下降,其余未见明显异常.两例聋哑者,其一女,5岁.1岁时因高烧咳嗽在某个体诊所肌注青、链霉素2天后,因严重烦躁哭闹,睡眠中突然尖叫以及恐惧等来我院,经停用链霉素留观次日症状消失出院.40天后发现患儿语言、听力丧失.经多方就医,至今未能恢复.另一男,8岁.1.5岁时因扁桃体炎肌注青、链霉素,用药第5天患儿出现恶心、呕吐、步态不稳、睡眠差、易惊转来我院.考虑系SM毒性反应,经对症留观两天症状消失出院.回家后其家长发现患儿反应迟钝,约2个月后语言、听力逐渐丧失,至今未能恢
This article reports from 1984 to 1989 six domestic-made by the domestic sulfate streptomycin (SM) induced toxicity in 42 cases, including 26 males and 16 females, 7 to 9 months in 4 cases, 10 to 12 months in 12 cases , 1 to 2 years in 16 cases, 2 to 3 years in 10. Primary disease: bronchial pneumonia in 21 cases, acute tonsillitis in 7 cases, cervical lymph node tuberculosis in 2 cases, hilar lymph node in 4 cases, lobar pneumonia in 6 cases, Empyema in 2 cases.Pharmaceuticals: 42 cases were treated with SM (15 ~ 30mg / kg / day) intramuscular injection.Among them 36 cases with penicillin sodium salt, 6 cases of tuberculosis patients and the use of Remy sealed oral SM after the fastest toxic reaction 1 day, the latest 14 days .Clinical manifestations: irritability, crying, unstable sleep or easy to panic in 5 cases, pulling the hair or (and) ear pull, scratching the lips in 17 cases, headache with vomiting 12 cases, sudden screaming in sleep, 4 cases of crying, unsteady gait, and 4 cases of uncontrollable discomfort.Proportion: After the withdrawal of toxic reaction, the disappearance time was the fastest 8 hours and the slowest 12 days.All the patients were followed up for 33 cases In 2 cases of deaf and dumb, 14 cases of high-frequency hearing loss, the other no obvious abnormalities, two cases of deaf-mute, one female, 5 years old .1 years old due to fever cough in a certain clinic intramuscular injection of streptomycin Two days later, due to severe irritability crying, sudden screaming and fear of sleep Fear to come to our hospital, after stopping the use of streptomycin to observe the next day the symptoms disappear discharged .40 days after the discovery of children with language, hearing loss after multiple medical treatment, has failed to restore another male, 8 years old .1.5 years due to tonsils Inflammation note green, streptomycin, medication on the 5th day children with nausea, vomiting, unstable gait, poor sleep, easy to surprise to our hospital. Considering the SM toxicity, symptoms of symptomatic two days to disappear after discharge After returning home, their parents found that children with unresponsive, about 2 months after the language, the gradual loss of hearing, so far failed to restore