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精神安定剂合并三环抗抑郁剂已用于治疗具有抑郁症状的精神分裂症、和具有分裂-情感性症状的抑郁症。本文报告有关这两类药物在药物动力学上相互影响的一项研究。8名精神分裂症患者口服或静注一个试验量的~(14)C-丙咪嗪,与此同时,和在此前后,给予奋乃静20～48mg/天(5名)、氯丙嗪300mg/天(1名)、氯哌丁苯12—20mg/天(2名)、三氟噻吨3—6mg/天(2名),取尿液作放射性测定,发现在给予上述精神安定剂过程中,尿中放射性丙咪嗪代谢物排泄量,除给服三氟噻吨者不变外,其余经测出都减少达25—50%。5名精神分裂症患者,口服另一种标记三环抗抑郁剂~(14)C-去甲替林,与此同时和前后~β,给予奋乃静
Spirit stabilizers combined with tricyclic antidepressants have been used to treat schizophrenia with depressive symptoms and depression with schizophrenic-affective symptoms. This article reports on a pharmacokinetic interaction of these two classes of drugs in a study. Eight patients with schizophrenia were orally or intravenously administered a test dose of ~ (14) C-imipramine, and meanwhile, before and after, 20 to 48 mg of perphenazine (5), chlorpromazine 300mg / day (1), clopidogrel 12-20mg / day (2), trifluoxetine 3-6mg / day (2), taking urine for radioactive determination and found that the spirit of the above-mentioned stabilizer In the process, the excretion of radioactive imipramine metabolites in the urine was unchanged by 25 to 50% as measured by the remaining trifluoperazine. Five patients with schizophrenia were orally given another tricyclic antidepressant labeled with ~ (14) C-nortriptyline, and at the same time, before and after ~