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众多研究认为内淋巴代谢紊乱所致内淋巴积水引起美尼尔氏病。有人认为美尼尔氏病的发作是内淋巴系统破裂和高钾内淋巴神经毒性作用。Kimura用阻断豚鼠内淋巴囊及管的方法制成美尼尔氏病模型,学者用该模型观察到AP阈值提高,甘露醇可影响AP调谐曲线,造模一年后EP约降低20mV/及Na~+浓度显著增加等现象。为研竞该病的发作机理,作者用玻璃微电极将高钾溶液(KCl155mM,CaCl_2z3mM)经豚鼠耳蜗螺旋韧带分别注入底转和第二转。注入后CM振幅立即下降至较低乎或消失,而EP只有数毫伏短暂的升高。这说明无前庭膜破裂及
Numerous studies have suggested that endolymphatic hydrops caused by disorders of endolymphatic metabolism causes Meniere’s disease. Some people think that the onset of Meniere’s disease is endolymphatic system rupture and high potassium endolymphatic neurotoxicity. Kimura blocked the guinea pig lymphatic sac and tube method of making the model of Meniere’s disease, scholars using the model observed AP threshold increased, mannitol AP tuning curve can be affected, one year after modeling EP decreased about 20mV / Na ~ + concentration increased significantly and so on. To study the pathogenesis of the disease, the authors use the glass microelectrode high potassium solution (KCl155mM, CaCl 2z3mM) were injected into the guinea pig cochlear spiral ligament, respectively, by the end and the second turn. Immediately after injection, the CM amplitude decreased to a lesser extent or disappeared, whereas the EP amplitude was only briefly increased by a few millivolts. This shows no rupture of anterior chamber membrane and