肿瘤转移是癌细胞从原发部位转移到远端部位形成肿瘤的过程。近年来的研究表明,细胞中基因表达的改变与肿瘤侵袭转移的发生、发展有着密切的联系。除DNA序列自身的改变外,DNA甲基化、微小RNA(microRNAs)的作用、组蛋白修饰以及染色质重塑等亦是造成基因表达改变的调控途径。本文主要就这些调控途径在肿瘤侵袭转移中的作用进行综述。 Tumor metastasis is the process by which cancer cells move from the primary site to the distal site to form tumors. In recent years, studies have shown that changes in cell gene expression and invasion and metastasis of tumor occurrence and development are closely linked. In addition to the DNA sequence itself, DNA methylation, the role of microRNAs, histone modifications, and chromatin remodeling are also regulatory pathways that alter gene expression. This review summarizes the roles of these regulatory pathways in tumor invasion and metastasis.