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神经发生是脊椎动物正常的中枢神经系统所具有的内在的生物学特性。老年化将使脑组织逐渐丧失正常神经发生的环境,从而使脑组织支持神经祖细胞生长和分化的能力下降,并阻碍神经发生。以APP的过度表达和PS 1的变异导致的神经发生障碍为主要特征的早老性痴呆(AD)病是老年痴呆中最常见的类型之一。在成体脑中移植的神经干细胞能分化为区域特化的神经元,并产生成熟神经元的生理特征,这使干细胞移植成为治疗神经发生障碍的新途径。
Neurogenesis is the intrinsic biological characteristic of a vertebrate normal central nervous system. Aging causes the brain tissue to gradually lose its normally neurogenic environment, thereby reducing the ability of brain tissue to support the growth and differentiation of neural progenitor cells and hindering neurogenesis. Alzheimer’s disease (AD), which is characterized by the over-expression of APP and the neurogenic disorder caused by PS 1 mutation, is one of the most common types of Alzheimer’s disease. Neural stem cells transplanted in adult brains can differentiate into zone-specific neurons and produce the physiological characteristics of mature neurons, making stem cell transplantation a new approach to the treatment of neurogenic disorders.