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在动植物基因组中广泛存在一类非编码蛋白的小RNA,即microRNA(miRNA)。miRNA在肿瘤的形成和转录后调节基因表达中起重要作用。miR-15a和miR-16-1表达水平的改变与慢性淋巴细胞白血病(CLL)有关,原癌基因bcl-2可能是miR-15a和miR-16-1的靶基因;活化B细胞型弥漫性大B细胞淋巴瘤(DLBCL)、儿童Burkitt淋巴瘤等肿瘤细胞miR-155的拷贝数明显增高,认为miR-155表达水平可以作为DLBCL诊断和预后的重要指标;miR-17-92簇(miR-15a,miR-16-1,miR-155,miR-17-92cluster,miR-142)是一组可能的肿瘤相关基因。
A wide range of small non-coding proteins, microRNAs (miRNAs), are widely found in animal and plant genomes. MiRNAs play an important role in the regulation of gene expression after tumor formation and transcription. The changes of miR-15a and miR-16-1 expression are related to chronic lymphocytic leukemia (CLL). The oncogene bcl-2 may be the target gene of miR-15a and miR-16-1. The activated B cell type diffuse The copy number of miR-155 in tumor cells such as large B-cell lymphoma (DLBCL) and childhood Burkitt lymphoma was significantly increased, and the expression of miR-155 was considered as an important index for the diagnosis and prognosis of DLBCL. MiR- 15a, miR-16-1, miR-155, miR-17-92cluster, miR-142) are a group of possible tumor-associated genes.