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目的研究胃癌组织中P16和P53蛋白的表达及临床意义。方法应用免疫组织化学方法,对57例胃癌组织和癌旁组织、38例正常胃组织中p16和p53基因表达产物进行检测,并结合临床进行讨论和分析。结果胃癌组织中P16蛋白的阳性率为21.1%(12/57),明显低于癌旁组织59.6%(34/57)和正常胃组织89.5%(34/38,P<0.05);P53蛋白的阳性率为80.7%(46/57),明显高于癌旁黏膜组织42.1%(24/57)和正常胃组织0%(0/38,P<0.05)。P16和P53蛋白表达与胃癌组织学类型、浸润深度、分化程度及淋巴结转移有关(P<0.05)。结论胃癌组织P16和P53蛋白的异常表达与胃癌发生发展、淋巴结转移和预后可能有关。
Objective To study the expression of P16 and P53 protein in gastric carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of p16 and p53 in 57 cases of gastric cancer tissues and adjacent normal tissues and 38 cases of normal gastric tissues. The clinical data were analyzed and discussed. Results The positive rate of P16 protein in gastric cancer was 21.1% (12/57), which was significantly lower than that in paracancerous tissues (59.6%, 34/57) and normal gastric tissues (89.5%, 34/38, P <0.05) The positive rate was 80.7% (46/57), which was significantly higher than that in adjacent mucosa (42.1%, 24/57) and normal gastric tissue (0%, 0/38, P <0.05). P16 and P53 protein expression and histological types of gastric cancer, depth of invasion, differentiation and lymph node metastasis (P <0.05). Conclusion The abnormal expression of P16 and P53 in gastric cancer may be related to the occurrence and development of gastric cancer, lymph node metastasis and prognosis.